| Reverse triiodothyronine | |
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(2S)-2-Amino-3-[4-(4-hydroxy-3,5-diiodophenoxy)-3-iodophenyl]propanoic acid |
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| Identifiers | |
| CAS number | 5817-39-0 |
| PubChem | 22069 |
| MeSH | Reverse+triiodothyronine |
| Jmol-3D images | Image 1 |
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| Properties | |
| Molecular formula | C15H12I3NO4 |
| Molar mass | 650.974 |
| (verify) (what is: /?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) |
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| Infobox references | |
Reverse triiodothyronine (3,3',5'-Triiodothyronine, reverse T3, or rT3) is a molecule that is an isomer of triiodothyronine (T3). It is derived from thyroxine (T4) through the action of deiodinase.
rT3, unlike T3, does not stimulate thyroid hormone receptors. However, rT3 binds to these receptors, thereby blocking the action of T3. Under stress conditions, the adrenal glands produce excess amounts of cortisol. Cortisol inhibits the conversion of T4 to T3, thus shunting T4 conversion from T3 towards rT3. As a consequence, there is a widespread shutdown in T3 binding across the body. This condition is termed Reverse T3 Dominance. It results in reduced body temperature, which slows the action of many enzymes, leading to a clinical syndrome, Multiple Enzyme Dysfunction, which produces the effects seen in hypothyroidism. Effects include fatigue, headache, migraine, PMS, irritability, fluid retention, anxiety and panic.
rT3 increases in conditions such as sick euthyroid syndrome
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